Anti-neurofascin autoantibody and demyelination
نویسندگان
چکیده
منابع مشابه
Anti-neurofascin antibody in patients with combined central and peripheral demyelination.
OBJECTIVES We aimed to identify the target antigens for combined central and peripheral demyelination (CCPD). METHODS We screened target antigens by immunohistochemistry and immunoblotting using peripheral nerve tissues to identify target antigens recognized by serum antibodies from selected CCPD and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) cases. We then measured the ...
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Axonal injury is considered the major cause of disability in patients with multiple sclerosis (MS), but the underlying effector mechanisms are poorly understood. Starting with a proteomics-based approach, we identified neurofascin-specific autoantibodies in patients with MS. These autoantibodies recognize the native form of the extracellular domains of both neurofascin 186 (NF186), a neuronal p...
متن کاملNeurofascin-155 as a putative antigen in combined central and peripheral demyelination
Combined central and peripheral demyelination (CCPD) encompasses a wide array of disorders ranging from myeloradiculoneuritis and encephalomyeloradiculoneuritis, which often occur after infection or vaccination, to co-occurrence of multiple sclerosis (MS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Antibodies directed to neurofascin-155 (NF155), a protein expressed in ...
متن کاملDisruption of neurofascin localization reveals early changes preceding demyelination and remyelination in multiple sclerosis.
Saltatory conduction in the nervous system is enabled through the intimate association between the leading edge of the myelin sheath and the axonal membrane to demarcate the node of Ranvier. The 186 kDa neuron specific isoform of the adhesion molecule neurofascin (Nfasc186) is required for the clustering of voltage gated Na+ channels at the node, whilst the 155 kDa glial specific isoform (Nfasc...
متن کاملCharacterization of IgG4 anti-neurofascin 155 antibody-positive polyneuropathy
OBJECTIVE To investigate anti-neurofascin 155 (NF155) antibody-positive chronic inflammatory demyelinating polyneuropathy (CIDP). METHODS Sera from 50 consecutive CIDP patients diagnosed in our clinic, 32 patients with multiple sclerosis, 40 patients with other neuropathies including 26 with Guillain-Barré syndrome (GBS)/Fisher syndrome, and 30 healthy controls were measured for anti-NF antib...
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ژورنال
عنوان ژورنال: Neurochemistry International
سال: 2019
ISSN: 0197-0186
DOI: 10.1016/j.neuint.2018.12.011